Rapid Folding and Unfolding of Apaf-1 CARD
نویسندگان
چکیده
منابع مشابه
Folding and Unfolding
The results of this thesis concern folding of one-dimensional objects in two dimensions: planar linkages. More precisely, a planar linkage consists of a collection of rigid bars (line segments) connected at their endpoints. Foldings of such a linkage must preserve the connections at endpoints, preserve the bar lengths, and (in our context) prevent bars from crossing. The main result of this the...
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Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the hyperactive state of the processed caspase-9. The underlying molecular mechanisms for these activities remain poorly characterized. Here we report that the isolated Apaf-1 caspase recruitment domain (CARD) forms a large hetero-oligomer with the active caspase-9. The catalytic activity of caspase-9 is significantly e...
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We consider a nonstatistical, computationally fast experiment to identify important topological constraints in folding small globular proteins of about 100-200 amino acids. In this experiment, proteins are expanded mechanically along a path of steepest increase in the free space around residues. The pathways are often consistent with folding scenarios reported in kinetics experiments and most a...
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Phylogenetic networks are rooted, labelled directed acyclic graphswhich are commonly used to represent reticulate evolution. There is a close relationship between phylogenetic networks and multi-labelled trees (MUL-trees). Indeed, any phylogenetic network N can be "unfolded" to obtain a MUL-tree U(N) and, conversely, a MUL-tree T can in certain circumstances be "folded" to obtain aphylogenetic ...
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Folding and unfolding problems have been implicit since Albrecht Dürer in the early 1500’s [Dür77], but have not been studied extensively until recently. Over the past few years, there has been a surge of interest in these problems in discrete and computational geometry. This paper gives a brief survey of some of the recent work in this area, subdivided into three sections based on the type of ...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2007
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2007.02.105